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The Essence: The Best of October 2022

By Anne-Margaret Olsson posted 11-15-2022 13:39

The Artery is your community for finding solutions to your day-to-day clinical chemistry questions. Last month, several answers were found to questions ranging from "Does your lab use reference ranges provided by the vendor?" to “How does your lab properly calculate eGFR with the MDRD equation?".  Read on for the most discussed on the Artery in October.

Reference Ranges – Which Ones Do You Use?
@Adil Khan, PhD.

Does your lab use reference ranges provided by the vendor or do you use ranges that are from reference textbooks? Vendor ranges do not always specify by age while textbook ranges specify by age and gender. Which method does your lab use?

hCG as a Tumor Marker
@David Alter, MD DABCC

Human chorionic gonadotropin (hCG) has not been approved by the Food and Drug Administration as a tumor marker, however, multiple in vitro diagnostic inserts state that hCG can be used in testing for cancer patients. Laboratorians are curious as to why hCG has yet to be validated for this purpose. What are your thoughts?

eGFR Reporting
@David Alter, MD DABCC

Laboratorians aim to understand how to properly calculate eGFR with the MDRD equation, specifically for values greater than 90. Arterians weigh in with their advice and experience using the equation. How does your lab handle this issue?